Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6376517 | 0.81 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL7835598 | 0.80 | KDM4E (0.55) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL20261932 | 0.76 | MAOA (0.50) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL10338392 | 0.74 | L3MBTL1 (0.48) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL9615083 | 0.72 | KDM4E (0.44) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL10997291 | 0.71 | KDM4E (0.43) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL11633686 | 0.70 | KDM4E (0.44) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL11095067 | 0.69 | HPGD (0.54) | ALDH1A1L3MBTL1KDM4ECYP1A2CYP2C9 | |
| SCHEMBL1338236 | 0.68 | CYP11B2 (0.33) | ALDH1A1KDM4E | |
| SCHEMBL29379576 | 0.68 | CYP11B2 (0.33) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1295890-B1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | TOYAMA CHEMICAL CO LTD (JP) | 2005-04-27 | — | — | EP | disclosed |
| EP-1256588-B1 | NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH | TOYAMA CHEMICAL CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6800629-B2 | VIRICIDES | TOYAMA CHEMICAL CO., LTD. (JP) | 2004-10-05 | — | — | US | disclosed |
| US-20030130213-A1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2003-07-10 | — | — | US | disclosed |
| EP-1295890-A1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2003-03-26 | — | — | EP | disclosed |
| EP-1256588-A1 | NOVEL PYRAZINE DERIVATIVES OR SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE DERIVATIVES OR THE SALTS AND INTERMEDIATES FOR THE PREPARATION OF BOTH | TOYAMA CHEMICAL CO., LTD. (JP) | 2002-11-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030130213-A1 | Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof | GTF3C5, EIF2AK2, GTF3C2 | ALDH1A1 734/4885L3MBTL1 4305/4885KDM4E 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.