Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.49 |
| ▸ | UTS2R | Q9UKP6 | 8/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6823392 | 0.93 | HTR7 (0.49) | HTR7UTS2RHTR1ADRD2HTR2A | |
| SCHEMBL7351045 | 0.93 | HTR7 (0.47) | HTR7UTS2RHTR1ASSTR5KCNH2 | |
| SCHEMBL6824741 | 0.92 | HTR7 (0.47) | HTR7UTS2RHTR1ADRD2HTR2A | |
| SCHEMBL6820545 | 0.92 | HTR7 (0.50) | HTR7UTS2RHTR1ADRD2HTR2A | |
| SCHEMBL6820574 | 0.91 | HTR7 (0.47) | HTR7UTS2RHTR1ADRD2HTR2A | |
| SCHEMBL6820561 | 0.90 | UTS2R (0.45) | HTR7UTS2RHTR1ADRD2SSTR5 | |
| SCHEMBL6378452 | 0.90 | HTR7 (0.46) | HTR7UTS2RHTR1ADRD2HTR2A | |
| SCHEMBL6824180 | 0.90 | UTS2R (0.49) | HTR7UTS2RHTR1APOLBCCR5 | |
| SCHEMBL6824129 | 0.89 | HTR7 (0.43) | HTR7UTS2RHTR1ADRD4CCR5 | |
| SCHEMBL6824342 | 0.88 | HTR7 (0.43) | HTR7UTS2RHTR1ASSTR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | claimed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | claimed |
| EP-1012147-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | claimed |
| WO-1999006387-A2 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-02-11 | — | — | WO | claimed |
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |
| US-6200989-B1 | ADMINISTERING AS UROKINASE PLASMINOGEN ACTIVATOR ANTAGONISTS, ANTITUMOR AND ANTIMETASTASIS AGENTS | HOFFMANN-LA ROCHE INC. | 2001-03-13 | — | — | US | disclosed |