Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CPS1 | P31327 | 2/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9720067 | 0.83 | PTGS2 (0.56) | MAPK1ALDH1A1ARPTGS2PTGS1 | |
| SCHEMBL4602327 | 0.81 | SMN1; SMN2 (0.68) | MAPK1ALDH1A1ARPTGS2PTGS1 | |
| SCHEMBL2934843 | 0.78 | ALDH1A1 (0.56) | MAPK1HPGDALDH1A1CYP3A4LMNA | |
| SCHEMBL14294261 | 0.77 | RAB9A (0.48) | MAPK1HPGDARPTGS2HTT | |
| SCHEMBL5631648 | 0.77 | MAPT (0.55) | MAPK1HPGDALDH1A1CYP3A4LMNA | |
| SCHEMBL22319299 | 0.76 | ALDH1A1 (0.57) | MAPK1HPGDALDH1A1CYP3A4AR | |
| SCHEMBL29639738 | 0.75 | ALDH1A1 (0.65) | MAPK1HPGDALDH1A1CYP3A4LMNA | |
| SCHEMBL531399 | 0.75 | ALDH1A1 (0.65) | MAPK1HPGDALDH1A1CYP3A4LMNA | |
| SCHEMBL23397361 | 0.74 | CYP1A1 (0.48) | HPGDALDH1A1CYP3A4ARPTGS2 | |
| SCHEMBL12922047 | 0.74 | ALDH1A1 (0.50) | MAPK1HPGDALDH1A1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065155-A1 | Novel pyridazine derivatives and medicines containing the same as effective ingredients | KOWA CO., LTD. (JP) | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065155-A1 | Novel pyridazine derivatives and medicines containing the same as effective ingredients | IL1B, TLR1, IRAK1 | MAPK1 145/4885HPGD 435/4885ALDH1A1 464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.