SCHEMBL640435

SCHEMBL640435

Nc1cccc2c1=NC(=O)N=2

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.33
TSHR P16473 2/20 0.33
ALDH1A1 P00352 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
HPGD P15428 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PTPRC P08575 1/20 0.32
ADORA2A P29274 1/20 0.32
PIK3CA P42336 1/20 0.32
ALOX15 P16050 1/20 0.32
CASP1 P29466 1/20 0.32
CASP7 P55210 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PARP1 P09874 3/20 0.32
AURKA O14965 1/20 0.31
AURKB Q96GD4 1/20 0.31
INCENP Q9NQS7 1/20 0.31
RECQL P46063 1/20 0.31
ELANE P08246 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25418829 1.00 CYP3A4 (0.33) CYP3A4TSHRALDH1A1TDP1HPGD
SCHEMBL7487292 0.83 CYP3A4 (0.33) CYP3A4TSHRALDH1A1TDP1HPGD
Hydrochloric Acid SCHEMBL9386686 0.77 ALDH1A1 (0.45) CYP3A4TSHRALDH1A1TDP1HPGD
SCHEMBL4652146 0.76
SCHEMBL1515006 0.74 CA12 (0.31) PARP1
SCHEMBL7724583 0.74 DBH (0.37) CYP3A4TSHRALDH1A1TDP1HPGD
SCHEMBL11218287 0.74 TSHR (0.38) CYP3A4TSHRALDH1A1TDP1PARP1
SCHEMBL6362215 0.74
SCHEMBL4420230 0.74 CES2 (0.33) PARP1
SCHEMBL15322617 0.74 THRB (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 202 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924961-A Preparation method of C.I. pigment orange 68 德州学院 2024-04-26 CN claimed
US-20160136077-A1 OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST L'OREAL (FR) 2016-05-19 US claimed
EP-3010473-A2 OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST L'OREAL (FR) 2016-04-27 EP claimed
WO-2014202792-A2 OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST L'OREAL (FR) 2014-12-24 WO claimed
CN-101838244-B Organic solvent synthetic method of azoic coupling component ASBI SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD 2012-11-21 CN claimed
CN-102532035-A Method for synthesizing azoic coupling component AS-BI XIANGRONG GUO 2012-07-04 CN claimed
CN-102503896-A Methylacryloyl-benzimidazole (sulfur) ketone derivative and application of serving as antibacterial agent thereof UNIV NORTHWEST A&F 2012-06-20 CN claimed
CN-102453917-A Corrosion inhibitor of carbon dioxide removal system and application thereof CHINA PETROLEUM & CHEMICAL 2012-05-16 CN claimed
CN-102002002-A Preparation method of 5-aminobenzimidazole ZHANGJIAGANG CITY LANDISEN NEW MATERIAL TECHNOLOGY CO LTD 2011-04-06 CN claimed
CN-101838244-A Organic solvent synthetic method of azoic coupling component ASBI SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD 2010-09-22 CN claimed
CN-101307023-B Production process of 5-acetyl acetamino benzimidazolone DONGYING TIANZHENG CHEMICAL & IND CO LTD 2010-09-22 CN claimed
CN-101307023-A Production process of 5-acetyl acetamino benzimidazolone DONGYING TIANZHENG CHEMICAL & (CN) 2008-11-19 CN claimed
CN-100339442-C Method for preparing organic pigment of red benzimidazolones UNIV HUADONG TECHNOLOGY (CN) 2007-09-26 CN claimed
CN-1974559-A Skeleton nickel catalyzed 5-nitrobenzimidazole ketone reducing process for preparing 5-aminobenzimidazole ketone UNIV TIANJIN (CN) 2007-06-06 CN claimed
CN-1230469-C Process for preparing red benzimidazolone pigments SHANGYU SHUNLIAN CHEMICAL INDU (CN) 2005-12-07 CN claimed
CN-1563202-A Method for preparing organic pigment of red benzimidazolones UNIV HUADONG TECHNOLOGY (CN) 2005-01-12 CN claimed
CN-1557877-A Process for preparing red benzimidazolone pigments 上虞舜联化工有限公司 2004-12-29 CN claimed
EP-0012983-B1 DIAMINOPHENYL UREAS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE PREPARATION OF AMINOBENZIMIDAZOLONES-(2) HOECHST AKTIENGESELLSCHAFT (DE) 1982-03-31 EP claimed
JP-62169819-A None JP disclosed
US-3963694-A AZO PIGMENTS, POLYESTERS, CELLULOSE ETHERS AND ESTERS CIBA-GEIGY CORPORATION (US) 1976-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160136077-A1 OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING AN AMINOBENZIMIDAZOLONE OXIDATION BASE AND A METAL CATALYST KRT18, CYB5R3, AOC3 CYP3A4 502/4885TSHR 4010/4885ALDH1A1 379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.