Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 6/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16516779 | 0.83 | CYP3A4 (0.37) | CYP3A4TDP1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL645528 | 0.83 | ALDH1A1 (0.45) | CYP3A4TDP1ALDH1A1TSHRHSD17B10 | |
| SCHEMBL13067866 | 0.82 | PDE4A (0.51) | TDP1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5315348 | 0.81 | HDAC11 (0.50) | HTR2CALDH1A1HSD17B10PDE4APDE4B | |
| SCHEMBL5315345 | 0.81 | HDAC11 (0.50) | HTR2CALDH1A1HSD17B10PDE4APDE4B | |
| SCHEMBL13067865 | 0.80 | HDAC11 (0.49) | ALDH1A1HSD17B10PDE4APDE4BPDE4C | |
| SCHEMBL13310487 | 0.80 | RARA (0.49) | TDP1MEN1NR1I2LMNAPGR | |
| SCHEMBL851880 | 0.80 | ENPP2 (0.36) | CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13310493 | 0.79 | HDAC2 (0.64) | — | |
| SCHEMBL7052653 | 0.79 | HTR2C (0.46) | HTR2CTDP1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141696-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2015-05-21 | — | — | US | claimed |
| US-8871972-B2 | Process for the preparation of adapalene and related compounds | JORDI PUIG SERRANO (ZA) | 2014-10-28 | — | — | US | claimed |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (ES) | 2013-01-31 | — | — | US | claimed |
| US-8119834-B2 | Process for the preparation of adapalene and related compounds | MEDICHEM, S.A. (ES) | 2012-02-21 | — | — | US | claimed |
| EP-1902010-B1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2011-11-30 | — | — | EP | claimed |
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | MEDICHEM, S.A. (ES) | 2009-05-21 | — | — | US | claimed |
| EP-1902010-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | Medichem, S.A. (ES) | 2008-03-26 | — | — | EP | claimed |
| WO-2007072217-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (US) | 2007-06-28 | — | — | WO | claimed |
| US-20150141696-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2015-05-21 | — | — | US | disclosed |
| US-8871972-B2 | Process for the preparation of adapalene and related compounds | JORDI PUIG SERRANO (ZA) | 2014-10-28 | — | — | US | disclosed |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (ES) | 2013-01-31 | — | — | US | disclosed |
| US-8119834-B2 | Process for the preparation of adapalene and related compounds | MEDICHEM, S.A. (ES) | 2012-02-21 | — | — | US | disclosed |
| EP-1902010-B1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM SA (ES) | 2011-11-30 | — | — | EP | disclosed |
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | MEDICHEM, S.A. (ES) | 2009-05-21 | — | — | US | disclosed |
| EP-1902010-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | Medichem, S.A. (ES) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007072217-A2 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | MEDICHEM, S.A. (US) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131713-A1 | Process for the Preparation of Adapalene and Related Compounds | DHPS, SQLE, CYP51A1 | HTR2C 4319/4885CYP3A4 506/4885TDP1 1586/4885 |
| US-20150141696-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | DHPS, SQLE, CYP51A1 | HTR2C 4319/4885CYP3A4 506/4885TDP1 1586/4885 |
| US-20130030214-A1 | PROCESS FOR THE PREPARATION OF ADAPALENE AND RELATED COMPOUNDS | DHPS, SQLE, CYP51A1 | HTR2C 4319/4885CYP3A4 506/4885TDP1 1586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.