Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.72 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | GMNN | O75496 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | PIM1 | P11309 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.68 |
| ▸ | CCKBR | P32239 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8809733 | 0.89 | RAB9A (0.66) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL6230239 | 0.87 | RAB9A (0.72) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL8812360 | 0.86 | RAB9A (0.70) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL8809191 | 0.85 | NAMPT (0.67) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL20456411 | 0.84 | RAB9A (0.68) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL11441650 | 0.84 | RAB9A (0.72) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL7558642 | 0.82 | RAB9A (0.65) | RAB9ANPC1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8813278 | 0.82 | RAB9A (0.65) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL15711547 | 0.82 | RAB9A (0.65) | RAB9ANPC1ALDH1A1HSD17B10LMNA | |
| SCHEMBL9812368 | 0.82 | RAB9A (0.78) | RAB9ANPC1LMNASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170173008-A1 | ANTIMICROBIAL AGENTS AND SCREENING METHODS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-06-22 | — | — | US | disclosed |
| US-7691890-B2 | Anti-viral uses of leflunomide products | Williams, James W. (US) | 2010-04-06 | — | — | US | disclosed |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | BOOJAMRA CONSTANTINE G | 2010-01-28 | — | — | US | disclosed |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | CANNIZZARO CARINA | 2009-09-10 | — | — | US | disclosed |
| US-7470724-B2 | Phosphonate compounds having immuno-modulatory activity | GILEAD SCIENCES, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-20050158371-A1 | Novel external agent | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2005-07-21 | — | — | US | disclosed |
| US-6387934-B1 | RHEUMATIC DISEASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6172103-B1 | TREATING BONE DISORDERS, OSTEOPOROSIS, AND ARTHRITIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-09 | — | — | US | disclosed |
| US-6121316-A | BONE DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |
| EP-0829470-B1 | 2-Cyano-3,5-dihydroxy-hex-2-ene carboxamide derivatives, process for their preparation and their use as medicaments | HOECHST AG (DE) | 1999-12-15 | — | — | EP | disclosed |
| EP-0829470-A1 | 2-Cyano-3,5-dihydroxy-hex-2-ene carboxamide derivatives, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | PHOSPHO1, NFATC1, IFNG | RAB9A 1550/4885NPC1 1397/4885ALDH1A1 4028/4885 |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | RAB9A 3453/4885NPC1 2610/4885ALDH1A1 3467/4885 |
| US-20050158371-A1 | Novel external agent | S100P, FIBP, TSLP | RAB9A 4280/4885NPC1 1735/4885ALDH1A1 1633/4885 |
| US-20170173008-A1 | ANTIMICROBIAL AGENTS AND SCREENING METHODS | BAK1, DCLRE1B, BLVRB | RAB9A 3085/4885NPC1 2327/4885ALDH1A1 4273/4885 |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | PIK3CA, PHOSPHO1, PTEN | RAB9A 1324/4885NPC1 1815/4885ALDH1A1 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.