Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421629 | 0.70 | MAOA (0.33) | MAOBMAOAFTODYRK1A | |
| SCHEMBL486181 | 0.66 | MAOA (0.55) | MAOBMAOAFTO | |
| SCHEMBL7452979 | 0.64 | MAOA (0.52) | MAOBMAOAFTO | |
| SCHEMBL1421578 | 0.62 | MAOA (0.49) | MAOBMAOAFTOACHEDYRK1A | |
| SCHEMBL3295735 | 0.60 | ALDH1A1 (0.37) | MAOBMAOAFTO | |
| SCHEMBL29957486 | 0.60 | MAPT (0.41) | MAOBMAOAFTONQO2 | |
| SCHEMBL7680403 | 0.57 | MAOB (0.45) | MAOBMAOAFTOACHEDYRK1A | |
| SCHEMBL17786447 | 0.57 | ALDH1A1 (0.40) | MAOBMAOAFTOACHEDYRK1A | |
| SCHEMBL2883909 | 0.57 | MAPT (0.56) | ACHEDYRK1ANQO2 | |
| SCHEMBL11412674 | 0.57 | MAOB (0.50) | MAOBMAOAFTOACHEKCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1297556-C | New benzo[b]chromeno-naphthyridin-7-one and pyrano[2',3':7,8] quino[2,3-b]quinoxalin-7-one compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2007-01-31 | — | — | CN | disclosed |
| EP-1561753-A2 | Benzo[b]chromenonapthyridin-7-one and pyrano[2',3':7,8]quino[2,3-b]Quinoxalin-7-one derivatives, process of synthesis, pharmaceutical compositions and their antitumoral properties for the treatment of cancer | Les Laboratoires Servier (FR) | 2005-08-10 | — | — | EP | disclosed |