Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PNMT | P11086 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL986160 | 0.89 | SIGMAR1 (0.53) | SIGMAR1DRD4PNMTMC4RACHE | |
| SCHEMBL8440094 | 0.88 | PNMT (0.51) | SIGMAR1TMEM97DRD4HTR2BADRA2A | |
| SCHEMBL10625310 | 0.86 | ALDH1A1 (0.45) | SIGMAR1TMEM97DRD4MEN1KMT2A | |
| SCHEMBL10620206 | 0.85 | LMNA (0.45) | SIGMAR1DRD4MEN1KMT2ADRD3 | |
| SCHEMBL10620962 | 0.85 | SIGMAR1 (0.48) | SIGMAR1HTR1ASLC6A3 | |
| SCHEMBL10620955 | 0.83 | MAPT (0.44) | MEN1KMT2AACHE | |
| SCHEMBL8439334 | 0.80 | PNMT (0.53) | SIGMAR1HTR2BHRH1PNMTHTR1A | |
| SCHEMBL15033587 | 0.80 | HTT (0.39) | SIGMAR1TMEM97DRD4HTR2BMEN1 | |
| SCHEMBL31134754 | 0.76 | ACHE (0.66) | SIGMAR1TMEM97DRD4HTR2BADRA2A | |
| SCHEMBL10978742 | 0.76 | ACHE (0.66) | SIGMAR1TMEM97DRD4HTR2BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |
| US-5998433-A | THERAPY FOR HYPERLIPIDEMIA; ATHEROSCLEROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| CN-1160403-A | Substd. heterobicyclic alkyl amines and their use as squalene oxide cyclase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-09-24 | — | — | CN | disclosed |
| EP-0785939-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | Takeda Chemical Industries, Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011201-A1 | SUBSTITUTED HETEROBICYCLIC ALKYL AMINES AND THEIR USE AS SQUALENE OXIDE CYCLASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-04-18 | — | — | WO | disclosed |
| EP-0011447-B1 | BLOOD PLATELET AGGREGATION INHIBITORY 1-BENZYL-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID DERIVATIVES AND SALTS THEREOF; PHARMACEUTICAL COMPOSITIONS THEREOF; AND ANALOGY PROCESSES FOR THE MANUFACTURE THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-01-05 | — | — | EP | disclosed |
| US-4238488-A | ANTICOAGULANTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1980-12-09 | — | — | US | disclosed |
| EP-0011447-A1 | Blood platelet aggregation inhibitory 1-benzyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid derivatives and salts thereof; pharmaceutical compositions thereof; and analogy processes for the manufacture thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-05-28 | — | — | EP | disclosed |