Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | THPO | P40225 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 11/20 | 0.52 |
| ▸ | HTR1B | P28222 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006099 | 0.79 | SLC6A4 (0.53) | NOS1NOS3NOS2 | |
| SCHEMBL7010984 | 0.79 | SLC6A4 (0.53) | NOS1NOS3NOS2 | |
| SCHEMBL7006286 | 0.79 | HTR1B (0.58) | HTR1DHTR1BHTR1ANOS1NOS3 | |
| SCHEMBL7006270 | 0.79 | HTR1B (0.58) | HTR1DHTR1BHTR1ANOS1NOS3 | |
| SCHEMBL6999829 | 0.78 | SLC6A4 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL7005001 | 0.78 | HTR1A (0.47) | CYP1A2CYP2D6CYP2C9HTR1DHTR1B | |
| SCHEMBL7007340 | 0.75 | HTR1D (0.58) | CYP1A2CYP3A4CYP2D6CYP2C9THPO | |
| SCHEMBL6426403 | 0.73 | HTR6 (0.48) | MAPT | |
| SCHEMBL6740915 | 0.73 | HTR6 (0.48) | MAPT | |
| SCHEMBL6997941 | 0.72 | SLC6A4 (0.41) | NOS1NOS3NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | claimed |
| EP-1098896-B1 | 5-BICYCLOINDOLE COMPOUNDS | NPS ALLELIX CORP (CA) | 2003-06-25 | — | — | EP | disclosed |