Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431520 | 0.81 | KMT2A (0.39) | LMNAGAACRHR1 | |
| SCHEMBL6428405 | 0.68 | HTR1A (0.35) | LMNAKCNH2ATM | |
| SCHEMBL6430830 | 0.68 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL6466890 | 0.67 | CRHR1 (0.37) | LMNAGAACRHR1RAPGEF4 | |
| SCHEMBL5789078 | 0.66 | CRHR1 (0.50) | CRHR1RAPGEF4 | |
| SCHEMBL14446507 | 0.66 | LMNA (0.60) | LMNAGAARAPGEF4 | |
| SCHEMBL18725691 | 0.63 | FDPS (0.40) | KCNH2ATM | |
| SCHEMBL5844351 | 0.62 | CRHR1 (0.53) | CRHR1RAPGEF4 | |
| SCHEMBL6430842 | 0.61 | LMNA (0.39) | LMNAGAACRHR1RAPGEF4 | |
| SCHEMBL7013499 | 0.61 | CRHR1 (0.44) | LMNAGAACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |
| US-20010007867-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | CHEN YUHPYNG L (US) | 2001-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007867-A1 | SUBSTITUTED 6,5-HETERO-BICYCLIC DERIVATIVES | CYP2D6, CYP2B6, CYP3A5 | LMNA 2532/4885GAA 986/4885CRHR1 2026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.