Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | HSPA5 | P11021 | 6/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HSPA2 | P54652 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.40 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443712 | 0.86 | CTSL (0.51) | CTSLHSPA5CTSBCTSSRAB9A | |
| SCHEMBL6442766 | 0.85 | CTSL (0.65) | CTSLHSPA5CTSBCTSSHSPA2 | |
| SCHEMBL6443478 | 0.84 | CTSB (0.51) | CTSLHSPA5CTSBCTSSRAB9A | |
| SCHEMBL6818989 | 0.84 | CTSL (0.54) | CTSLHSPA5CTSBCTSSRAB9A | |
| SCHEMBL6020253 | 0.81 | CTSL (0.47) | CTSLCTSBCTSSRAB9ALMNA | |
| SCHEMBL6443541 | 0.80 | CTSL (0.51) | CTSLHSPA5CTSBCTSSRAB9A | |
| SCHEMBL6019834 | 0.79 | CTSL (0.48) | CTSLHSPA5CTSBCTSSRAB9A | |
| SCHEMBL6020898 | 0.78 | CTSB (0.38) | CTSLCTSBCTSSKDM4EALDH1A1 | |
| SCHEMBL6922718 | 0.78 | ECE1 (0.58) | CTSLLMNAKDM4EMEN1MAPT | |
| SCHEMBL6020891 | 0.78 | LMNA (0.46) | RAB9ALMNAALDH1A1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |