Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.65 |
| ▸ | HSPA5 | P11021 | 3/20 | 0.53 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.53 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.53 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 5/20 | 0.47 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | CTSK | P43235 | 3/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6818989 | 0.91 | CTSL (0.54) | CTSLHSPA5HSPA1AHSPA9HSPA2 | |
| SCHEMBL6443541 | 0.88 | CTSL (0.51) | CTSLHSPA5HSPA1AHSPA9HSPA2 | |
| SCHEMBL6447088 | 0.86 | CTSL (0.68) | CTSLHSPA5HSPA1AHSPA9HSPA2 | |
| SCHEMBL6441980 | 0.85 | CTSL (0.49) | CTSLHSPA5HSPA1AHSPA9HSPA2 | |
| SCHEMBL6021192 | 0.85 | CTSL (0.62) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6443478 | 0.83 | CTSB (0.51) | CTSLHSPA5HSPA1AHSPA9HSPA2 | |
| SCHEMBL6019834 | 0.83 | CTSL (0.48) | CTSLHSPA5CTSSCTSBCTSK | |
| SCHEMBL6020216 | 0.82 | CTSK (0.60) | CTSLCTSSCTSBCTSKCTSC | |
| SCHEMBL6021087 | 0.82 | CTSL (0.48) | CTSLCTSSCTSBCTSKCTSC | |
| SCHEMBL6020647 | 0.81 | CTSS (0.58) | CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |