Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 11/20 | 0.54 |
| ▸ | CTSS | P25774 | 8/20 | 0.54 |
| ▸ | CTSL | P07711 | 10/20 | 0.46 |
| ▸ | CTSB | P07858 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443484 | 0.93 | CTSK (0.55) | CTSKCTSSCTSLCTSBLMNA | |
| SCHEMBL6447527 | 0.89 | LMNA (0.41) | CTSKCTSSLMNANPC1RAB9A | |
| SCHEMBL6449654 | 0.88 | CTSK (0.56) | CTSKCTSSCTSLCTSBGAA | |
| SCHEMBL6442329 | 0.86 | ATM (0.51) | CTSKCTSSCTSLCTSBLMNA | |
| SCHEMBL6443540 | 0.84 | CTSK (0.60) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6445280 | 0.84 | CTSK (0.51) | CTSKCTSSCTSLCTSBLMNA | |
| SCHEMBL6443471 | 0.83 | RAB9A (0.46) | CTSKCTSSCTSLLMNANPC1 | |
| SCHEMBL6442268 | 0.81 | KDM4E (0.58) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6442378 | 0.79 | GAA (0.47) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6825007 | 0.79 | KDM4E (0.47) | CTSKCTSSCTSLLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |