Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.60 |
| ▸ | CTSS | P25774 | 10/20 | 0.60 |
| ▸ | CTSL | P07711 | 12/20 | 0.58 |
| ▸ | CTSB | P07858 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5517758 | 0.92 | CTSK (0.61) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL5529775 | 0.90 | CTSK (0.60) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6443745 | 0.89 | CTSS (0.47) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL5528992 | 0.89 | CTSK (0.58) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6446405 | 0.87 | CTSL (0.50) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6449654 | 0.86 | CTSK (0.56) | CTSKCTSSCTSLCTSB | |
| SCHEMBL5532550 | 0.86 | CTSK (0.55) | CTSKCTSSCTSLCTSBNPC1 | |
| SCHEMBL6448227 | 0.86 | CTSS (0.47) | CTSKCTSSCTSLCTSBSMN1; SMN2 | |
| SCHEMBL6822562 | 0.85 | CTSK (0.47) | CTSKCTSSCTSLCTSB | |
| SCHEMBL6822952 | 0.85 | CTSL (0.61) | CTSKCTSSCTSLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |