Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447527 | 0.92 | LMNA (0.41) | RAB9ANPC1CTSSCTSKMEN1 | |
| SCHEMBL6443484 | 0.89 | CTSK (0.55) | RAB9ANPC1CTSSCTSKMEN1 | |
| SCHEMBL6448077 | 0.88 | KDM4E (0.54) | RAB9ANPC1CTSSCTSKMEN1 | |
| SCHEMBL6447483 | 0.87 | ATM (0.49) | RAB9ANPC1CTSSCTSKMEN1 | |
| SCHEMBL6443588 | 0.84 | NPC1 (0.51) | RAB9ANPC1CTSSCTSKCTSL | |
| SCHEMBL6472461 | 0.83 | CTSD (0.46) | RAB9ANPC1CTSSCTSKMEN1 | |
| SCHEMBL6442799 | 0.83 | CTSK (0.54) | RAB9ANPC1CTSSCTSKMEN1 | |
| SCHEMBL30827958 | 0.82 | NPC1 (0.60) | RAB9ANPC1MEN1KMT2ALMNA | |
| SCHEMBL6825007 | 0.82 | KDM4E (0.47) | CTSSCTSKMEN1KMT2ACTSL | |
| SCHEMBL6822581 | 0.81 | GAA (0.43) | RAB9ANPC1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | disclosed |