Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.47 |
| ▸ | CTSL | P07711 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | GLI1 | P08151 | 1/20 | 0.37 |
| ▸ | GLI2 | P10070 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6443588 | 0.93 | NPC1 (0.51) | CTSSCTSKCTSLNPC1RAB9A | |
| SCHEMBL6443540 | 0.89 | CTSK (0.60) | CTSSCTSKCTSLNPC1RAB9A | |
| SCHEMBL6825007 | 0.87 | KDM4E (0.47) | CTSSCTSKCTSLCNR1CNR2 | |
| SCHEMBL6443632 | 0.86 | SFN (0.42) | CTSSCTSKCTSLNPC1RAB9A | |
| SCHEMBL6447322 | 0.85 | CTSK (0.42) | CTSSCTSKCTSLNPC1RAB9A | |
| SCHEMBL6445190 | 0.85 | GUSB (0.40) | CTSSCTSKCTSLCTSBGUSB | |
| SCHEMBL6446308 | 0.85 | SMN1; SMN2 (0.42) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6442129 | 0.84 | CTSL (0.49) | CTSLNPC1 | |
| SCHEMBL6447527 | 0.84 | LMNA (0.41) | CTSSCTSKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6442019 | 0.83 | CTSS (0.42) | CTSSCTSKCTSLNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |