Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.83 |
| ▸ | MGLL | Q99685 | 5/20 | 0.83 |
| ▸ | FAAH | O00519 | 3/20 | 0.83 |
| ▸ | HPGD | P15428 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PHGDH | O43175 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399380 | 0.91 | ALDH1A1 (1.00) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL6380824 | 0.87 | MGLL (0.72) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL5924440 | 0.86 | ALDH1A1 (0.68) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL4394405 | 0.81 | ALDH1A1 (1.00) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL6578765 | 0.81 | FAAH (0.62) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL4397261 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL1108678 | 0.76 | MGLL (0.82) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL9529297 | 0.76 | ALDH1A1 (0.71) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL11564701 | 0.74 | MGLL (0.56) | ALDH1A1MGLLFAAHHPGDMAPT | |
| SCHEMBL12590360 | 0.74 | ALDH1A1 (0.72) | ALDH1A1MGLLFAAHHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226128-B1 | NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2005-02-23 | — | — | EP | disclosed |
| US-6716845-B2 | Barbituric acid derivatives | HOFFMANN-LA ROCHE INC. | 2004-04-06 | — | — | US | disclosed |
| EP-1383746-A2 | NEW PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-28 | — | — | EP | disclosed |
| US-6498252-B1 | Pyrimidine-2,4,6-trione derivatives, processes for their production and pharmaceutical agents containing these compounds | HOFFMANN-LA ROCHE INC. | 2002-12-24 | — | — | US | disclosed |
| US-20020187991-A1 | Barbituric acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-12 | — | — | US | disclosed |
| WO-2002079170-A2 | PYRIMIDINE-2,4,6-TRIONE DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020187991-A1 | Barbituric acid derivatives | GABBR1, GABBR2, TUBB6 | ALDH1A1 159/4885MGLL 4796/4885FAAH 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.