Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.52 |
| ▸ | CTSS | P25774 | 3/20 | 0.52 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6445280 | 0.93 | CTSK (0.51) | CTSKCTSSCTSLCTSDALDH1A1 | |
| SCHEMBL6472461 | 0.90 | CTSD (0.46) | CTSKCTSSCTSLCTSDALDH1A1 | |
| SCHEMBL6441987 | 0.88 | CTSK (0.46) | CTSKCTSSCTSLCTSDALDH1A1 | |
| SCHEMBL6442268 | 0.84 | KDM4E (0.58) | CTSKCTSSCTSLHTTKMT2A | |
| SCHEMBL6447040 | 0.84 | CTSD (0.49) | CTSDALDH1A1HPGDHTTLMNA | |
| SCHEMBL6445664 | 0.83 | ALDH1A1 (0.45) | CTSKCTSSCTSDALDH1A1HPGD | |
| SCHEMBL6441973 | 0.83 | CTSD (0.48) | CTSDALDH1A1HPGDHTTLMNA | |
| SCHEMBL6443484 | 0.82 | CTSK (0.55) | CTSKCTSSCTSLLMNAMEN1 | |
| SCHEMBL6448400 | 0.82 | HPGD (0.43) | CTSKCTSSCTSLCTSDALDH1A1 | |
| SCHEMBL5517758 | 0.80 | CTSK (0.61) | CTSKCTSSCTSLCTSBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575903-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | Jerini AG (DE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004065353-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES | JERINI AG (DE) | 2004-08-05 | — | — | WO | claimed |
| WO-2004056755-A2 | COMPOUNDS FOR THE INHIBITION OF NON-PROTEOLYTIC ENZYMES | JERENI AG (DE) | 2004-07-08 | — | — | WO | disclosed |