Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.61 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 6/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CDC42 | P60953 | 1/20 | 0.59 |
| ▸ | RAC1 | P63000 | 1/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38666256 | 1.00 | ABCB11 (0.61) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL26462966 | 1.00 | ABCB11 (0.61) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL23255698 | 1.00 | ABCB11 (0.61) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL30640494 | 0.83 | ABCB11 (0.65) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL487168 | 0.83 | ABCB11 (0.65) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL29365195 | 0.83 | ABCB11 (0.65) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL20398797 | 0.83 | ABCB11 (0.65) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL3831944 | 0.82 | ABCB11 (0.54) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL15701616 | 0.82 | ABCB11 (0.62) | ABCB11AKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL365643 | 0.81 | TDP1 (0.56) | TSHRCYP1A2MAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6555704-B1 | Preparation of alpha-aryl-propionic acids such as ibuprofen by carbonylating the corresponding 1-arylethyl halide in an acidic aqueous medium containing a phosphine/palladium catalyst; catalyst selectivity; efficiency | BASF CORPORATION | 2003-04-29 | — | — | US | claimed |
| US-6268526-B1 | MIXTURE FORMED FROM AN AROMATIC SUBSTITUTED ALCOHOL AND/OR AN AROMATIC SUBSTITUTED ALKYL HALIDE, AND A COPPER-FREE PALLADIUM CATALYST IS CARBONYLATED WITH CARBON MONOXIDE TO PRODUCE ALPHA-SUBSTITUTED CARBOXYLIC ACID OR ESTER | ALBEMARLE CORPORATION | 2001-07-31 | — | — | US | claimed |
| EP-0338852-B1 | Process for the carbonylation of arylalkyl halides | HOECHST CELANESE CORP (US) | 1994-11-30 | — | — | EP | claimed |
| EP-0338852-A1 | Process for the carbonylation of arylalkyl halides | HOECHST CELANESE CORPORATION (US) | 1989-10-25 | — | — | EP | claimed |
| US-4536595-A | Process for the preparation of alpha-aryl-propionic acids and alkaline salts thereof | MONTEDISON S.P.A. (IT) | 1985-08-20 | — | — | US | claimed |
| EP-0076722-B1 | PROCESS FOR THE PREPARATION OF ALPHA-ARYL-PROPIONIC ACIDS AND THEIR ALKALINE SALTS | Montedison S.p.A. (IT) | 1985-02-20 | — | — | EP | claimed |
| EP-0076721-B1 | PROCESS FOR THE CARBONYLATION OF SECONDARY BENZYL HALIDES | Montedison S.p.A. (IT) | 1985-02-06 | — | — | EP | claimed |
| EP-0076722-A1 | Process for the preparation of alpha-aryl-propionic acids and their alkaline salts | Montedison S.p.A. (IT) | 1983-04-13 | — | — | EP | claimed |
| EP-0076721-A1 | Process for the carbonylation of secondary benzyl halides | Montedison S.p.A. (IT) | 1983-04-13 | — | — | EP | claimed |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | SRI INTERNATIONAL (US) | 2023-05-02 | — | — | US | disclosed |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | SRI INTERNATIONAL (US) | 2023-05-02 | — | — | US | disclosed |
| US-20210114962-A1 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | SRI INTERNATIONAL | 2021-04-22 | — | — | US | disclosed |
| US-20050283020-A1 | Process for the preparation of 2-aryl propionic acids | CHAUDHARI RAGHUNATH V | 2005-12-22 | — | — | US | disclosed |
| US-6660883-B1 | Conversion of aryl alkyl compound such as aryl alkyl alcohols and aryl alkyl halides | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-12-09 | — | — | US | disclosed |
| EP-0338852-A1 | Process for the carbonylation of arylalkyl halides | HOECHST CELANESE CORPORATION (US) | 1989-10-25 | — | — | EP | disclosed |
| US-4536595-A | Process for the preparation of alpha-aryl-propionic acids and alkaline salts thereof | MONTEDISON S.P.A. (IT) | 1985-08-20 | — | — | US | disclosed |
| EP-0076722-B1 | PROCESS FOR THE PREPARATION OF ALPHA-ARYL-PROPIONIC ACIDS AND THEIR ALKALINE SALTS | Montedison S.p.A. (IT) | 1985-02-20 | — | — | EP | disclosed |
| EP-0076721-B1 | PROCESS FOR THE CARBONYLATION OF SECONDARY BENZYL HALIDES | Montedison S.p.A. (IT) | 1985-02-06 | — | — | EP | disclosed |
| EP-0076721-A1 | Process for the carbonylation of secondary benzyl halides | Montedison S.p.A. (IT) | 1983-04-13 | — | — | EP | disclosed |
| EP-0076722-A1 | Process for the preparation of alpha-aryl-propionic acids and their alkaline salts | Montedison S.p.A. (IT) | 1983-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050283020-A1 | Process for the preparation of 2-aryl propionic acids | ADH1C, ADH5, ADH1A | ABCB11 2023/4885AKR1C3 20/4885AKR1C2 132/4885 |
| US-20210114962-A1 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | PTGES2, PTGS2, PTGES | ABCB11 276/4885AKR1C3 284/4885AKR1C2 616/4885 |
| US-11639326-B2 | Continuous flow synthesis of ibuprofen | PTGES2, PTGS2, PTGES | ABCB11 276/4885AKR1C3 284/4885AKR1C2 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.