Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325791 | 0.91 | BLM (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL6447202 | 0.84 | KMT2A (0.46) | NPC1RAB9ASMN1; SMN2PTGER3XDH | |
| SCHEMBL6449238 | 0.84 | CSNK2A2 (0.52) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL6445872 | 0.83 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL6444242 | 0.83 | RAB9A (0.52) | NPC1RAB9ASMN1; SMN2PTGER3ALDH1A1 | |
| SCHEMBL6445978 | 0.83 | SNCA (0.47) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL6451642 | 0.83 | WNT3A (0.39) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL6445912 | 0.83 | ALDH1A1 (0.50) | NPC1RAB9ACSNK2A2CSNK2A1PTGER3 | |
| SCHEMBL6447053 | 0.82 | CSNK2A2 (0.49) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2A1 | |
| SCHEMBL6445760 | 0.82 | CSNK2A2 (0.52) | NPC1RAB9ASMN1; SMN2CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-30 | — | — | US | claimed |
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | NPC1 1404/4885RAB9A 1792/4885SMN1; SMN2 2751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.