Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 9/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447328 | 0.94 | FFAR1 (0.48) | FFAR1MMP2MMP12PTGDR2CYP2C9 | |
| SCHEMBL6447480 | 0.88 | FFAR1 (0.43) | FFAR1MMP2MMP12PTGDR2CYP2C9 | |
| SCHEMBL6446075 | 0.80 | FFAR1 (0.50) | FFAR1MMP2MMP12PTGDR2KDM4E | |
| SCHEMBL4683194 | 0.79 | FFAR1 (0.57) | FFAR1PTGDR2CYP2C9ALOX5LMNA | |
| SCHEMBL5633251 | 0.78 | ALDH1A1 (0.47) | FFAR1MMP2MMP12CYP2C9KDM4E | |
| SCHEMBL7050853 | 0.73 | ALDH1A1 (0.41) | FFAR1MMP2MMP12CYP2C9ALOX5 | |
| SCHEMBL75765 | 0.73 | PTGDR2 (0.51) | FFAR1MMP2MMP12PTGDR2CYP2C9 | |
| SCHEMBL30852830 | 0.70 | MMP2 (0.55) | FFAR1MMP2MMP12KDM4ELMNA | |
| SCHEMBL32144372 | 0.70 | FFAR1 (0.47) | FFAR1ALDH1A1 | |
| SCHEMBL82303 | 0.70 | FFAR1 (0.47) | FFAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960588-B1 | Tryptase inhibitors | ALTANA PHARMA AG (DE) | 2005-11-01 | — | — | US | disclosed |
| EP-1216236-A1 | TRYPTASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019809-A1 | TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-03-22 | — | — | WO | disclosed |