Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6453166 | 0.82 | CYP1A2 (0.58) | PTGS2PTGS1TRPA1ALDH1A1KDM4E | |
| SCHEMBL6449517 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL6449438 | 0.81 | PTGS2 (0.46) | PTGS2PTGS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL6449543 | 0.80 | NFE2L2 (0.54) | PTGS2PTGS1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL10496446 | 0.78 | JUN (0.60) | KDM4ECYP1A1CYP1A2CYP1B1MAPT | |
| SCHEMBL9798046 | 0.78 | JUN (0.60) | KDM4ECYP1A1CYP1A2CYP1B1MAPT | |
| SCHEMBL6450699 | 0.76 | TUBB4A (0.62) | PTGS2PTGS1KDM4EHPGDCYP1A1 | |
| SCHEMBL9111913 | 0.75 | TNFRSF1A (0.64) | PTPN1ALDH1A1KDM4EHPGDCYP1A1 | |
| SCHEMBL9111920 | 0.75 | TNFRSF1A (0.64) | PTPN1ALDH1A1KDM4EHPGDCYP1A1 | |
| SCHEMBL10496420 | 0.74 | TRPA1 (0.63) | PTGS2PTGS1TRPA1TRPM8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554236-A1 | NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | Welichem Biotech Inc. (CA) | 2005-07-20 | — | — | EP | claimed |
| WO-2004031117-A1 | NOVEL BIOACTIVE DIPHENYL ETHENE COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS | WELICHEM BIOTECH INC. (CA) | 2004-04-15 | — | — | WO | claimed |