Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31285140 | 0.88 | TSHR (0.49) | ALDH1A1TDP1TSHRPOLBCYP3A4 | |
| SCHEMBL6446115 | 0.82 | HSD17B10 (0.49) | ALDH1A1MAPK1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL7933915 | 0.82 | GPR35 (0.46) | ALDH1A1TDP1TSHRPOLBMAPK1 | |
| SCHEMBL2659793 | 0.82 | CYP1A2 (0.51) | ALDH1A1POLBCYP3A4KMT2AMAPT | |
| SCHEMBL6179703 | 0.82 | LMNA (0.51) | ALDH1A1TDP1POLBCYP3A4MAPK1 | |
| SCHEMBL20085599 | 0.80 | KDM4E (0.50) | ALDH1A1TDP1TSHRPOLBNPC1 | |
| SCHEMBL31261399 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TDP1POLBCYP3A4SMN1; SMN2 | |
| SCHEMBL12306339 | 0.79 | MAPT (0.42) | ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL3156146 | 0.79 | LMNA (0.57) | ALDH1A1POLBSMN1; SMN2KMT2AMAPT | |
| SCHEMBL18146104 | 0.79 | ALDH1A1 (0.54) | ALDH1A1TDP1POLBCYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342765-B1 | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2021-09-15 | — | — | EP | disclosed |
| CN-107922315-B | Cathepsin K inhibitors and uses thereof | 广东东阳光药业有限公司 | 2021-03-26 | — | — | CN | disclosed |
| EP-3342765-A1 | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2018-07-04 | — | — | EP | disclosed |
| CN-107922315-A | CATHEPSIN K INHIBITOR AND APPLICATION THEREOF | 广东东阳光药业有限公司 | 2018-04-17 | — | — | CN | disclosed |
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | BRISTOL-MYERS SQUIBB COMPANY | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143384-A1 | Amide thiadiazole inhibitors of plasminogen activator inhibitor-1 | SERPINE1, SERPINC1, SERPINB1 | ALDH1A1 212/4885TDP1 855/4885TSHR 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.