Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.60 |
| ▸ | MAPT | P10636 | 11/20 | 0.60 |
| ▸ | MEN1 | O00255 | 8/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.60 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645648 | 0.81 | POLB (0.68) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL14464170 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL9656115 | 0.77 | LMNA (0.62) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL19501865 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL13848139 | 0.75 | MDM2 (0.81) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL11337959 | 0.75 | RAB9A (0.62) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL15765106 | 0.75 | RXRA (0.72) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL11337955 | 0.75 | RAB9A (0.62) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL5857925 | 0.75 | ALDH1A1 (0.55) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL5857932 | 0.74 | ALDH1A1 (0.58) | ALDH1A1MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119660-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119660-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-21 | — | — | US | disclosed |
| US-8119660-B2 | Small-molecule inhibitors of the androgen receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-01 | — | — | US | disclosed |
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-01 | — | — | US | disclosed |
| US-7696227-B2 | Small-molecule inhibitors of the androgen receptor | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| US-7696227-B2 | Small-molecule inhibitors of the androgen receptor | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| US-7696227-B2 | Small-molecule inhibitors of the androgen receptor | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008128100-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008128100-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168128-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | ALDH1A1 987/4885MAPT 4635/4885MEN1 924/4885 |
| US-20080293766-A1 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR | AR, GNRHR, FSHR | ALDH1A1 987/4885MAPT 4635/4885MEN1 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.