Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 10/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462598 | 0.92 | HTR7 (0.54) | SLC6A5HTR7HTR1AHTR2ADRD2 | |
| SCHEMBL6458101 | 0.92 | HTR7 (0.54) | SLC6A5HTR7HTR1AHTR2ADRD2 | |
| SCHEMBL6466592 | 0.91 | HTR7 (0.55) | SLC6A5HTR7HTR1AHTR2ADRD2 | |
| SCHEMBL6462987 | 0.90 | HTR7 (0.47) | HTR7HTR1A | |
| SCHEMBL6457124 | 0.89 | ADRA1D (0.50) | HTR7HTR1AHTR2ADRD2DRD3 | |
| SCHEMBL6461236 | 0.89 | HTR7 (0.46) | SLC6A5HTR7HTR1ADRD4 | |
| SCHEMBL6463130 | 0.88 | POLB (0.51) | SLC6A5HTR7HTR1AHTR2ADRD3 | |
| SCHEMBL6457221 | 0.87 | HTR7 (0.55) | HTR7HTR1AHTR2ADRD2DRD3 | |
| SCHEMBL7346972 | 0.87 | SLC6A5 (0.60) | SLC6A5HTR2ADRD2DRD4 | |
| SCHEMBL7345537 | 0.87 | SLC6A5 (0.44) | SLC6A5HTR7HTR1AHTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012147-B1 | O-SUBSTITUTED HYDROXYCUMARANONE DERIVATIVES AS ANTITUMOR AND ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2005-11-02 | — | — | EP | disclosed |