Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPN | P05981 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.59 |
| ▸ | VCAM1 | P19320 | 10/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497146 | 0.94 | HPN (0.56) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL648287 | 0.90 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL647467 | 0.82 | ALOX15 (0.68) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL647768 | 0.79 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL645860 | 0.79 | ALOX15 (0.68) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL648883 | 0.78 | VCAM1 (0.59) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL647898 | 0.77 | ALOX15 (0.59) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL11742489 | 0.76 | HPN (0.50) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL8699143 | 0.76 | HPN (0.53) | HPNMAPTALOX15SIRT5VCAM1 | |
| SCHEMBL10504856 | 0.76 | ALOX15 (0.63) | HPNMAPTALOX15SIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070919-B1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | HYKES LAB LLC (JP) | 2012-10-10 | — | — | EP | disclosed |
| US-8119686-B2 | Spiroquinone compound and pharmaceutical composition | HYKES LABORATORIES LLC (JP) | 2012-02-21 | — | — | US | disclosed |
| US-20100056613-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | HYKES LABORATORIES LLC (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2070919-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | Hykes Laboratories LLC (JP) | 2009-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056613-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | NR1H2, NR1H3, APOB | HPN 3356/4885MAPT 4362/4885ALOX15 2563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.