Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | HPN | P05981 | 1/20 | 0.68 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.68 |
| ▸ | VCAM1 | P19320 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647467 | 0.85 | ALOX15 (0.68) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL10504856 | 0.81 | ALOX15 (0.63) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL648287 | 0.81 | ALOX15 (0.63) | ALOX15MAPTHPNSIRT5VCAM1 | |
| Probucol SCHEMBL4150 | 0.81 | HPN (1.00) | ALOX15MAPTHPNSIRT5VCAM1 | |
| Probucol SCHEMBL5143451 | 0.81 | HPN (1.00) | ALOX15MAPTHPNSIRT5VCAM1 | |
| Probucol SCHEMBL8344652 | 0.79 | ALOX15 (0.95) | ALOX15MAPTHPNSIRT5VCAM1 | |
| Probucol SCHEMBL4620631 | 0.79 | ALOX15 (0.95) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL9506457 | 0.79 | HPN (0.79) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL646329 | 0.79 | HPN (0.59) | ALOX15MAPTHPNSIRT5VCAM1 | |
| SCHEMBL12791592 | 0.78 | ALOX15 (0.84) | ALOX15MAPTHPNSIRT5VCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070919-B1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | HYKES LAB LLC (JP) | 2012-10-10 | — | — | EP | disclosed |
| US-8119686-B2 | Spiroquinone compound and pharmaceutical composition | HYKES LABORATORIES LLC (JP) | 2012-02-21 | — | — | US | disclosed |
| US-20100056613-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | HYKES LABORATORIES LLC (JP) | 2010-03-04 | — | — | US | disclosed |
| EP-2070919-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | Hykes Laboratories LLC (JP) | 2009-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056613-A1 | SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION | NR1H2, NR1H3, APOB | ALOX15 2563/4885MAPT 4362/4885HPN 3356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.