Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.47 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.47 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.47 |
| ▸ | CBFB | Q13951 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112369 | 0.88 | PAX8 (0.55) | EGFRALDH1A1PAX8KDM4EMAPT | |
| SCHEMBL23999925 | 0.81 | MAP4K4 (0.52) | EGFRALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL16248015 | 0.80 | MEN1 (0.55) | EGFRMEN1KMT2AJAK2JAK1 | |
| SCHEMBL15043774 | 0.80 | SLC2A1 (0.53) | ALDH1A1KDM4EMAPTMEN1NPC1 | |
| SCHEMBL23999904 | 0.79 | EGFR (0.47) | EGFRALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL15520293 | 0.79 | EGFR (0.60) | EGFRALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL22492333 | 0.78 | SMN1; SMN2 (0.55) | EGFRALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL5989580 | 0.78 | KMT2A (0.56) | EGFRALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL27974973 | 0.77 | TDP1 (0.57) | EGFRALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL10436636 | 0.77 | HTR2C (0.49) | EGFRALDH1A1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2998296-B1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2018-03-14 | — | — | EP | disclosed |
| EP-2998296-B1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2018-03-14 | — | — | EP | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co., Lt.d (CN) | 2016-04-21 | — | — | US | disclosed |
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co., Lt.d (CN) | 2016-04-21 | — | — | US | disclosed |
| EP-2998296-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998296-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014183555-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | 上海恒瑞医药有限公司 (CN) | 2014-11-20 | — | — | WO | disclosed |
| US-6977259-B2 | Quinoline derivatives and their use as aurora 2 kinase inhibitors | ASTRAZENECA AB (SE) | 2005-12-20 | — | — | US | disclosed |
| US-20030105129-A1 | Chemical compounds | ASTRAZENECA AB (SE) | 2003-06-05 | — | — | US | disclosed |
| EP-1294709-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS AURORA 2 KINASE INHIBITORS | AstraZeneca AB (SE) | 2003-03-26 | — | — | EP | disclosed |
| WO-2001055116-A2 | QUINOLINE DERIVATIVES AND THEIR USE AS AURORA 2 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | UGP2, MPST, KYAT1 | EGFR 1482/4885ALDH1A1 182/4885PAX8 3691/4885 |
| US-20030105129-A1 | Chemical compounds | AURKC, AURKA, AURKB | EGFR 83/4885ALDH1A1 2111/4885PAX8 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.