Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061441 | 0.76 | ALDH1A1 (0.45) | ALDH1A1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL989581 | 0.72 | HTR1A (0.69) | LMNAKMT2ASMN1; SMN2MEN1HTR1A | |
| SCHEMBL6930428 | 0.72 | MEN1 (0.51) | ALDH1A1LMNAKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6713817 | 0.72 | ALDH1A1 (0.40) | ALDH1A1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL6719441 | 0.71 | OPRM1 (0.38) | ALDH1A1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL6723513 | 0.70 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6717391 | 0.70 | LMNA (0.38) | ALDH1A1LMNAKMT2AMEN1NPC1 | |
| SCHEMBL28840600 | 0.68 | ALDH1A1 (0.50) | ALDH1A1LMNAKMT2AKDM4EMEN1 | |
| SCHEMBL28328527 | 0.67 | ALDH1A1 (0.43) | ALDH1A1KMT2AKDM4EMEN1GAA | |
| SCHEMBL8618010 | 0.66 | ALDH1A1 (0.44) | ALDH1A1LMNAKMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176792-A1 | Ketone substituted benzimidazole compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| WO-2005070420-A1 | 1H-BENZIMIDAZOL-2-YL-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ITK INHIBITORS (INTERLEUKIN-2-INDUCIBLE T CELL KINASE) FOR THE TREATMENT OF INFLAMMATION, IMMUNOLOGICAL AND ALLERGIC DISORDERS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176792-A1 | Ketone substituted benzimidazole compounds | ITK, BLK, BCKDK | ALDH1A1 1041/4885LMNA 2004/4885KMT2A 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.