SCHEMBL6472489

SCHEMBL6472489

NC(=O)C(CC(O)(CCc1ccccc1)c1nc2ccccc2o1)C1CC2CCC1C2

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.36
CES1 P23141 1/20 0.36
DAGLA Q9Y4D2 1/20 0.36
LMNA P02545 3/20 0.35
MAPT P10636 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
GAA P10253 2/20 0.35
XDH P47989 2/20 0.33
ALDH1A1 P00352 4/20 0.33
NPC1 O15118 1/20 0.32
RAB9A P51151 1/20 0.32
HPGD P15428 2/20 0.31
PPARG P37231 2/20 0.31
PPARA Q07869 1/20 0.31
MEN1 O00255 1/20 0.31
TSHR P16473 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7112293 0.76 HPGD (0.44) FAAHCES1DAGLALMNAMAPT
SCHEMBL6463655 0.76 LMNA (0.39) FAAHCES1DAGLALMNAMAPT
SCHEMBL6466340 0.76 LMNA (0.39) FAAHCES1DAGLALMNAMAPT
SCHEMBL6462292 0.74 DAGLA (0.39) FAAHCES1DAGLALMNAMAPT
SCHEMBL6462568 0.73 METAP2 (0.37) FAAHCES1DAGLALMNAMAPT
SCHEMBL6467443 0.70 FAAH (0.36) FAAHCES1DAGLALMNAMAPT
SCHEMBL6466282 0.68 LMNA (0.39) FAAHCES1DAGLALMNAMAPT
SCHEMBL6464160 0.68 LMNA (0.39) FAAHCES1DAGLALMNAMAPT
SCHEMBL7045443 0.67 MEN1 (0.45) FAAHCES1DAGLALMNAMAPT
SCHEMBL7049306 0.67 DAGLA (0.44) FAAHCES1DAGLALMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1516877-A1 Amine derivatives as protease inhibitors AXYS PHARMACEUTICALS, INC. (US) 2005-03-23 EP disclosed