Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | FCER2 | P06734 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7047935 | 0.91 | LMNA (0.37) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL7043453 | 0.89 | LMNA (0.43) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL7049029 | 0.89 | RAB9A (0.38) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL7045974 | 0.88 | CTSS (0.43) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL6467035 | 0.87 | LMNA (0.47) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL6462862 | 0.85 | OPRD1 (0.37) | LMNAMAPTKMT2AALOX5TP53 | |
| SCHEMBL7048360 | 0.84 | HTT (0.45) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL6464160 | 0.82 | LMNA (0.39) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL6462741 | 0.81 | FAAH (0.36) | LMNAMAPTTSHRMEN1KMT2A | |
| SCHEMBL6063233 | 0.80 | FAAH (0.37) | LMNAMAPTTSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |