Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6463655 | 1.00 | LMNA (0.39) | LMNAMAPTALOX5FAAHCES1 | |
| SCHEMBL6465748 | 0.89 | LMNA (0.40) | LMNAKMT2ASMN1; SMN2XDHNPC1 | |
| SCHEMBL6462292 | 0.83 | DAGLA (0.39) | LMNAMAPTFAAHCES1DAGLA | |
| SCHEMBL6462679 | 0.81 | FAAH (0.37) | FAAHCES1TSHRMEN1KMT2A | |
| SCHEMBL6464160 | 0.80 | LMNA (0.39) | LMNAMAPTALOX5FAAHCES1 | |
| SCHEMBL6467443 | 0.79 | FAAH (0.36) | LMNAMAPTFAAHCES1DAGLA | |
| SCHEMBL6466282 | 0.76 | LMNA (0.39) | LMNAMAPTALOX5FAAHCES1 | |
| SCHEMBL6472489 | 0.76 | FAAH (0.36) | LMNAMAPTFAAHCES1DAGLA | |
| SCHEMBL7044868 | 0.76 | LMNA (0.37) | LMNAMAPTALOX5TSHRMEN1 | |
| SCHEMBL6462568 | 0.74 | METAP2 (0.37) | LMNAMAPTALOX5FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1516877-A1 | Amine derivatives as protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-23 | — | — | EP | disclosed |