Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017390 | 0.83 | DRD2 (0.42) | SMN1; SMN2PKMALDH1A1ERCC5FEN1 | |
| SCHEMBL6473589 | 0.83 | CYP1A2 (0.46) | MAPK1SMN1; SMN2ALDH1A1ERCC5FEN1 | |
| SCHEMBL6724880 | 0.82 | L3MBTL1 (0.43) | L3MBTL1MAPK1HTTSMN1; SMN2PKM | |
| SCHEMBL6257579 | 0.82 | DRD2 (0.41) | SMN1; SMN2PKMALDH1A1ERCC5FEN1 | |
| SCHEMBL7101392 | 0.81 | CHRM2 (0.41) | SMN1; SMN2ALDH1A1ERCC5FEN1MEN1 | |
| SCHEMBL6471284 | 0.80 | MEN1 (0.46) | HTTSMN1; SMN2PKMALDH1A1ERCC5 | |
| SCHEMBL6472164 | 0.79 | ERCC5 (0.43) | HTTSMN1; SMN2PKMALDH1A1ERCC5 | |
| SCHEMBL7106239 | 0.79 | POLB (0.47) | MAPK1HTTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6474542 | 0.78 | ADORA2B (0.44) | L3MBTL1MAPK1SMN1; SMN2PKMALDH1A1 | |
| SCHEMBL6476633 | 0.78 | ALDH1A1 (0.43) | HTTSMN1; SMN2PKMALDH1A1ERCC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530475-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | Warner-Lambert Company LLC (US) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004006931-A2 | PHARMACEUTICAL COMPOSTIONS COMPRISING AN ALLOSTERIC CARBOXYLIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | WARNER-LAMBERT COMPANY LLC (US) | 2004-01-22 | — | — | WO | disclosed |