Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ATIC | P31939 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6475761 | 0.90 | ESR1 (0.46) | MAPTPKMESR1LMNAHTR6 | |
| SCHEMBL4486179 | 0.89 | HTR6 (0.55) | MAPTPKMLMNAHTR6MEN1 | |
| SCHEMBL6472057 | 0.89 | PKM (0.45) | MAPTPKMLMNAHTR6MEN1 | |
| SCHEMBL6476587 | 0.81 | MAPT (0.54) | MAPTPKMLMNAHTR6KMT2A | |
| SCHEMBL16550876 | 0.78 | HTR6 (0.53) | MAPTPKMESR1HTR6CES1 | |
| SCHEMBL4482936 | 0.72 | HTR6 (0.81) | MAPTPKMESR1LMNAHTR6 | |
| SCHEMBL2227391 | 0.72 | HTR6 (0.53) | MAPTPKMHTR6CES1PNMT | |
| SCHEMBL13865317 | 0.70 | GAA (0.41) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16551297 | 0.69 | HTR6 (0.53) | HTR6 | |
| SCHEMBL5229664 | 0.69 | MAPT (0.97) | MAPTPKMLMNACES1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | claimed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |