Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486179 | 0.86 | HTR6 (0.55) | MAPTKMT2ATSHRHTR6LMNA | |
| SCHEMBL6472057 | 0.86 | PKM (0.45) | MAPTKMT2AHTR6PGRLMNA | |
| SCHEMBL6475761 | 0.82 | ESR1 (0.46) | MAPTKMT2AHTR6LMNASMN1; SMN2 | |
| SCHEMBL6473187 | 0.81 | MAPT (0.54) | MAPTKMT2AHTR6LMNASMN1; SMN2 | |
| SCHEMBL4784539 | 0.78 | MAPT (0.80) | MAPTHSD17B2KMT2ATSHRNR3C1 | |
| SCHEMBL6472087 | 0.75 | HTR6 (0.76) | MAPTHSD17B2KMT2ATSHRHTR6 | |
| SCHEMBL13506866 | 0.74 | HTR2C (0.43) | HTR6SCN5ASCN9A | |
| SCHEMBL5781608 | 0.71 | HTR6 (0.69) | MAPTHSD17B2KMT2ATSHRHTR6 | |
| SCHEMBL4195878 | 0.71 | NR3C1 (0.54) | MAPTHSD17B2TSHRHTR6NR3C1 | |
| SCHEMBL4195874 | 0.71 | NR3C1 (0.54) | MAPTHSD17B2TSHRHTR6NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | claimed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |