Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 3/20 | 0.49 |
| ▸ | CASP7 | P55210 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.49 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6473796 | 0.87 | MAPT (0.51) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL6473728 | 0.86 | MAPT (0.50) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL6474559 | 0.82 | GAA (0.43) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL5202344 | 0.80 | SCN9A (0.47) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL6474012 | 0.69 | BCL6 (0.52) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL31069736 | 0.69 | MAPT (0.81) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL13195727 | 0.69 | TLR7 (0.57) | — | |
| SCHEMBL5207250 | 0.69 | EGFR (0.45) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL5207244 | 0.69 | EGFR (0.45) | MAPTCASP1CASP7ALDH1A1LMNA | |
| SCHEMBL5204470 | 0.69 | MEN1 (0.42) | MAPTCASP1CASP7ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | claimed |