Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.43 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480285 | 0.90 | AURKA (0.53) | AURKATTBK1TTBK2RAB9AMAPT | |
| SCHEMBL5204622 | 0.88 | SCN9A (0.51) | AURKAKCNH2SCN5ASCN9ATTBK1 | |
| SCHEMBL6472908 | 0.88 | TTBK1 (0.43) | AURKAKCNH2SCN5ASCN9ATTBK1 | |
| SCHEMBL6474471 | 0.87 | BCL6 (0.49) | AURKASCN5ASCN9ATTBK1TTBK2 | |
| SCHEMBL6480339 | 0.87 | MAPT (0.44) | AURKARAB9AMAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5203439 | 0.86 | SCN9A (0.50) | AURKAKCNH2SCN5ASCN9ATTBK1 | |
| SCHEMBL6482639 | 0.83 | AURKA (0.41) | AURKARAB9AMAPTMEN1KMT2A | |
| SCHEMBL6474741 | 0.78 | SCN5A (0.42) | AURKAKCNH2SCN5ASCN9AMAPT | |
| SCHEMBL6474012 | 0.77 | BCL6 (0.52) | AURKAKCNH2SCN5ASCN9ATTBK1 | |
| SCHEMBL5205294 | 0.76 | MMP13 (0.40) | KCNH2SCN5ASCN9ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916820-B1 | Neurotrophic substituted pyrimidines | KRENITSKY PHARMACEUTICALS, INC. (US) | 2005-07-12 | — | — | US | claimed |