Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | SELL | P14151 | 1/20 | 0.50 |
| ▸ | SELP | P16109 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 2/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2059405 | 0.85 | TDP1 (0.53) | TDP1MAPTSELLSELPCSNK2A1 | |
| SCHEMBL419245 | 0.84 | TDP1 (0.56) | TDP1MAPTSELLSELPCSNK2A1 | |
| SCHEMBL1438720 | 0.82 | TDP1 (0.59) | TDP1MAPTSELLSELPCSNK2A1 | |
| SCHEMBL1919502 | 0.82 | TDP1 (0.50) | TDP1MAPTMYCHTTALDH1A1 | |
| SCHEMBL12683255 | 0.82 | TDP1 (0.70) | TDP1MAPTSELLSELPCSNK2A1 | |
| SCHEMBL1505827 | 0.81 | TDP1 (0.61) | TDP1MAPTPKMHTTALDH1A1 | |
| SCHEMBL4309406 | 0.81 | MAPT (0.62) | TDP1MAPTMYCPKMHTT | |
| SCHEMBL30463104 | 0.79 | SELL (0.64) | TDP1MAPTSELLSELPCSNK2A1 | |
| SCHEMBL565454 | 0.79 | SELL (0.64) | TDP1MAPTSELLSELPCSNK2A1 | |
| SCHEMBL288168 | 0.79 | TDP1 (0.47) | TDP1MAPTMYCHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112656954-A | Lipid formulations for delivery of messenger RNA | 夏尔人类遗传性治疗公司 | 2021-04-16 | — | — | CN | disclosed |
| CN-112618732-A | Lipid formulations for delivery of messenger RNA | 夏尔人类遗传性治疗公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-105813656-B | Lipid formulations for delivery of messenger RNA | 夏尔人类遗传性治疗公司 | 2021-01-15 | — | — | CN | disclosed |
| US-6930131-B2 | Aryl substituted 3-ethoxy phenyl trifluoromethane sulfonamides for the treatment of non-insulin dependent diabetes mellitus (NIDDM) | WYETH (US) | 2005-08-16 | — | — | US | disclosed |