Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.81 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | PLCB3 | Q01970 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482936 | 0.90 | HTR6 (0.81) | HTR6ESR1KMT2ALMNAMEN1 | |
| SCHEMBL4480862 | 0.90 | HTR6 (1.00) | HTR6BRD4KMT2ALMNASMN1; SMN2 | |
| Water SCHEMBL4559431 | 0.89 | HTR6 (0.98) | HTR6BRD4KMT2ALMNASMN1; SMN2 | |
| Water SCHEMBL4559433 | 0.89 | HTR6 (0.98) | HTR6BRD4KMT2ALMNASMN1; SMN2 | |
| SCHEMBL4477508 | 0.83 | HTR6 (0.80) | HTR6BRD4KMT2ALMNASMN1; SMN2 | |
| SCHEMBL6475723 | 0.83 | HTR6 (0.80) | HTR6BRD4LMNAKDM4ECCNT1 | |
| SCHEMBL6472087 | 0.83 | HTR6 (0.76) | HTR6KMT2ALMNASMN1; SMN2HSD17B2 | |
| SCHEMBL3324653 | 0.79 | HTR6 (0.72) | HTR6BRD4 | |
| SCHEMBL6475761 | 0.72 | ESR1 (0.46) | HTR6ESR1BRD4KMT2ALMNA | |
| SCHEMBL17495376 | 0.67 | RORC (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | claimed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |