Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL4559431 | 0.99 | HTR6 (0.98) | HTR6HPGDCCNT1CDK9DDB1 | |
| Water SCHEMBL4559433 | 0.99 | HTR6 (0.98) | HTR6HPGDCCNT1CDK9DDB1 | |
| SCHEMBL6476010 | 0.90 | HTR6 (0.81) | HTR6CCNT1CDK9LMNASMN1; SMN2 | |
| SCHEMBL4482936 | 0.90 | HTR6 (0.81) | HTR6CCNT1CDK9HTR2CLMNA | |
| SCHEMBL4477508 | 0.89 | HTR6 (0.80) | HTR6HPGDCCNT1CDK9LMNA | |
| SCHEMBL6475723 | 0.89 | HTR6 (0.80) | HTR6CCNT1CDK9DDB1CRBN | |
| SCHEMBL6472087 | 0.86 | HTR6 (0.76) | HTR6HTR2CLMNASMN1; SMN2MAPT | |
| SCHEMBL3324653 | 0.84 | HTR6 (0.72) | HTR6HTR2BBRD4ALDH1A1 | |
| SCHEMBL4487505 | 0.81 | HTR6 (0.68) | HTR6HPGDHTR2CLMNASMN1; SMN2 | |
| SCHEMBL4486179 | 0.71 | HTR6 (0.55) | HTR6HPGDCCNT1CDK9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534801-B2 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2009-05-19 | — | — | US | claimed |
| US-20050107431-A1 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-05-19 | — | — | US | claimed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | claimed |
| US-7534801-B2 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2009-05-19 | — | — | US | disclosed |
| US-20050107431-A1 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-05-19 | — | — | US | disclosed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107431-A1 | Piperidinylchromen-6-ylsulfonamide compounds as 5-hydroxytryptamine-6 ligands | HTR6, HTR5A, TPH1 | HTR6 1/4885HPGD 1923/4885CCNT1 2964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.