Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480862 | 0.86 | HTR6 (1.00) | HTR6MAPTLMNASMN1; SMN2HTR2C | |
| SCHEMBL4477508 | 0.86 | HTR6 (0.80) | HTR6MAPTHSD17B2PGRPTPN2 | |
| SCHEMBL6475723 | 0.86 | HTR6 (0.80) | HTR6MAPTPGRLMNA | |
| Water SCHEMBL4559431 | 0.86 | HTR6 (0.98) | HTR6MAPTLMNASMN1; SMN2HTR2C | |
| Water SCHEMBL4559433 | 0.86 | HTR6 (0.98) | HTR6MAPTLMNASMN1; SMN2HTR2C | |
| SCHEMBL6476010 | 0.83 | HTR6 (0.81) | HTR6HSD17B2LMNASMN1; SMN2KMT2A | |
| SCHEMBL4482936 | 0.81 | HTR6 (0.81) | HTR6MAPTLMNAHTR2CKMT2A | |
| SCHEMBL3324653 | 0.78 | HTR6 (0.72) | HTR6PGRPTPN2PTPN1PTPN5 | |
| SCHEMBL6476587 | 0.75 | MAPT (0.54) | HTR6MAPTHSD17B2NR3C1PGR | |
| SCHEMBL4195878 | 0.74 | NR3C1 (0.54) | HTR6MAPTHSD17B2NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | claimed |
| WO-2005037830-A1 | PIPERIDINYLCHROMEN-6-YLSULFONAMIDE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2005-04-28 | — | — | WO | disclosed |