Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ME2 | P23368 | 3/20 | 0.50 |
| ▸ | ME1 | P48163 | 3/20 | 0.50 |
| ▸ | ME3 | Q16798 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6349901 | 0.87 | HDAC1 (0.59) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL15331084 | 0.84 | HDAC1 (0.59) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL6478335 | 0.84 | HDAC1 (0.61) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL6350032 | 0.84 | ME2 (0.70) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL13981711 | 0.82 | HDAC1 (0.67) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL6479590 | 0.79 | ALDH1A1 (0.63) | HDAC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL7488568 | 0.78 | HDAC1 (0.62) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL4753923 | 0.78 | MAPT (0.62) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL5214510 | 0.78 | ME2 (0.57) | HDAC1SMN1; SMN2ME2ME1ME3 | |
| SCHEMBL30620934 | 0.77 | GPR119 (0.60) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050014942-A1 | Transforming growth factor inhibitor; controllign cell differentiation, cell proliferation | NIPPON SHINYAKU CO., LTD. (JP) | 2005-01-20 | — | — | US | disclosed |
| EP-1452525-A1 | AMIDE DERIVATIVES AND DRUGS | Nippon Shinyaku Co., Ltd. (JP) | 2004-09-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014942-A1 | Transforming growth factor inhibitor; controllign cell differentiation, cell proliferation | TGFBR1, TGFBR2, TGFB1 | HDAC1 211/4885SMN1; SMN2 3783/4885ME2 4720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.