Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.74 |
| ▸ | NPC1 | O15118 | 12/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | ALDH1A3 | P47895 | 3/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2404662 | 0.83 | RAB9A (1.00) | RAB9ANPC1MAPTKDM4EPKM | |
| SCHEMBL3433580 | 0.77 | NR4A2 (0.65) | RAB9ANPC1MAPTKDM4EPKM | |
| SCHEMBL28670403 | 0.74 | RAB9A (1.00) | RAB9ANPC1CASP3SMN1; SMN2SENP8 | |
| SCHEMBL4501121 | 0.73 | RAB9A (0.60) | RAB9ANPC1MAPTKDM4EPKM | |
| SCHEMBL1691409 | 0.73 | RAB9A (1.00) | RAB9ANPC1MAPTKDM4EPKM | |
| SCHEMBL16246713 | 0.73 | ALDH1A3 (1.00) | RAB9ANPC1KDM4EPKMALDH1A1 | |
| SCHEMBL13325769 | 0.73 | ALDH1A3 (1.00) | RAB9ANPC1KDM4EPKMALDH1A1 | |
| SCHEMBL3027391 | 0.72 | RAB9A (0.68) | RAB9ANPC1MAPTKDM4EPKM | |
| SCHEMBL23657665 | 0.71 | ALDH1A1 (0.69) | RAB9ANPC1MAPTKDM4EPKM | |
| SCHEMBL13325714 | 0.71 | RAB9A (0.69) | RAB9ANPC1MAPTKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050260126-A1 | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein | BF RESEARCH INSTITUTE (JP) | 2005-11-24 | — | — | US | disclosed |
| US-20050176700-A1 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases | ACTELION PHARMACEUTICALS LTD. (CH) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050260126-A1 | Diagnostic probes and remedies for diseases with accumulation of prion protein, and stains for prion protein | PRNP, PRPH, PCNP | RAB9A 1787/4885NPC1 147/4885MAPT 7/4885 |
| US-20050176700-A1 | 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension,cardiovascular or renal diseases | REN, AGTR1, ACE | RAB9A 107/4885NPC1 1326/4885MAPT 4578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.