SCHEMBL6489174

SCHEMBL6489174

Cc1cc(CNc2cccc(C(=O)O)n2)cc2c1nc(C)n2Cc1ccc(-c2ccccc2)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PIK3C2B O00750 3/20 0.37
ALOX5AP P20292 2/20 0.36
DCTPP1 Q9H773 3/20 0.35
PTGES O14684 1/20 0.35
ALOX5 P09917 1/20 0.35
LTC4S Q16873 1/20 0.35
TLR7 Q9NYK1 1/20 0.34
P2RX3 P56373 1/20 0.34
DHODH Q02127 1/20 0.34
ACLY P53396 1/20 0.34
AGTR1 P30556 1/20 0.34
CCR2 P41597 2/20 0.34
PPARG P37231 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6487346 0.90 ALDH1A1 (0.38) PIK3C2BALOX5APDCTPP1PTGESALOX5
SCHEMBL6500955 0.85 KDM4C (0.40) PIK3C2BALOX5APDCTPP1PTGESALOX5
SCHEMBL6502677 0.84 P2RX3 (0.40) PIK3C2BALOX5APDCTPP1P2RX3DHODH
SCHEMBL6492577 0.80 DCTPP1 (0.41) PIK3C2BALOX5APDCTPP1PTGESALOX5
SCHEMBL6488975 0.80 ALOX5AP (0.34) PIK3C2BALOX5APDCTPP1PTGESALOX5
SCHEMBL6486764 0.80 DCTPP1 (0.44) PIK3C2BALOX5APDCTPP1PTGESALOX5
SCHEMBL6496733 0.78 ALOX5AP (0.47) PIK3C2BALOX5APDCTPP1PTGESALOX5
SCHEMBL6501198 0.77 NR4A2 (0.48) ALOX5APDHODHPPARG
SCHEMBL6493027 0.77 MCL1 (0.43) PIK3C2BDHODHAGTR1
SCHEMBL6498493 0.76 DCTPP1 (0.40) PIK3C2BALOX5APDCTPP1PTGESALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD PIK3C2B 2433/4885ALOX5AP 4663/4885DCTPP1 1534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.