Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5141361 | 0.84 | TSHR (0.57) | ALDH1A1TSHRGFERKIF11NPC1 | |
| SCHEMBL12489603 | 0.82 | ALDH1A1 (0.83) | ALDH1A1MAPK1TSHRNPC1RAB9A | |
| SCHEMBL25973862 | 0.80 | TSHR (0.59) | ALDH1A1MAPK1TSHRGFERKIF11 | |
| SCHEMBL6674385 | 0.77 | CA12 (0.48) | TSHRGFERKIF11APPMEN1 | |
| SCHEMBL1047461 | 0.76 | ALDH1A1 (0.65) | ALDH1A1MAPK1TSHRNPC1RAB9A | |
| SCHEMBL23546571 | 0.75 | TSHR (0.46) | ALDH1A1TSHRGFERKIF11APP | |
| SCHEMBL4433057 | 0.75 | CYP2A6 (0.58) | MAPK1TSHRGFERKIF11APP | |
| SCHEMBL3786028 | 0.75 | ALDH1A1 (0.58) | ALDH1A1TSHRGFERKIF11NPC1 | |
| SCHEMBL17504140 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRGFERKIF11NPC1 | |
| SCHEMBL26029406 | 0.75 | TSHR (0.46) | ALDH1A1MAPK1TSHRGFERKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849648-B2 | Phenylene alkyne matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| EP-1434585-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2004-07-07 | — | — | EP | disclosed |
| US-20030144274-A1 | Alkyne matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2003-07-31 | — | — | US | disclosed |
| WO-2003032999-A1 | ALKYNE MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2003-04-24 | — | — | WO | disclosed |
| CN-1023006-C | Benzoylurea compounds, process for their production and pesticides contg. them | ISHIHARA SANGYO KAISHA (JP) | 1993-12-08 | — | — | CN | disclosed |
| CN-87106674-A | Benzoyl urea compound, process for producing the same, and agricultural chemical containing the same | — | 1988-08-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144274-A1 | Alkyne matrix metalloproteinase inhibitors | MMP11, MMP13, MMP3 | ALDH1A1 102/4885MAPK1 108/4885TSHR 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.