Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 13/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | COMT | P21964 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479325 | 0.85 | ALDH1A1 (0.49) | GPR35MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL6479173 | 0.80 | AKR1B1 (0.47) | GPR35COMTKDM4EALDH1A1GLA | |
| SCHEMBL6578678 | 0.79 | MAOA (0.57) | GPR35MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL6490859 | 0.78 | GPR35 (0.76) | GPR35MAOAMAOBCOMTALDH1A1 | |
| SCHEMBL11509771 | 0.77 | MAOB (0.54) | GPR35MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL6109204 | 0.73 | GPR35 (0.58) | GPR35MAOAMAOBALDH1A1HPGD | |
| SCHEMBL1406738 | 0.73 | MCL1 (0.53) | GPR35MAOAMAOBALDH1A1HPGD | |
| SCHEMBL27825688 | 0.72 | CDK2 (0.51) | GPR35COMTKDM4EALDH1A1HPGD | |
| SCHEMBL31113776 | 0.72 | GPR35 (0.50) | GPR35MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL11509776 | 0.70 | GPR35 (0.66) | GPR35MAOAMAOBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951870-B2 | Coumarin derivatives with COMT inhibiting activity | ORION CORPORATION (FI) | 2005-10-04 | — | — | US | disclosed |
| CN-1199963-C | Coumarin derivatives with COMT inhibiting activity | ORION CORP (FI) | 2005-05-04 | — | — | CN | disclosed |
| US-6846919-B2 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2005-01-25 | — | — | US | disclosed |
| US-20040110750-A9 | Coumarin derivatives with comt inhibiting activity | ORION CORPORATION (FI) | 2004-06-10 | — | — | US | disclosed |
| EP-1301503-B1 | COUMARIN DERIVATIVES WITH COMT INHIBITING ACTIVITY | ORION CORP (FI) | 2004-02-25 | — | — | EP | disclosed |
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | BEHAN DOMINIC P (US) | 2003-12-04 | — | — | US | disclosed |
| US-20030186975-A1 | Coumarin derivatives with comt inhibiting activity | PYSTYNEN JARMO (FI) | 2003-10-02 | — | — | US | disclosed |
| CN-1440399-A | Coumarin derivatives with COMT inhibiting activity | ORION CORP (FI) | 2003-09-03 | — | — | CN | disclosed |
| US-20030153004-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. | 2003-08-14 | — | — | US | disclosed |
| US-6541209-B1 | Bioassay; identification of compounds as agonists; use in treatment of diseases and disorders that are related to 5-HT2A and or 5-HT2C serotonin receptors | ARENA PHARMACEUTICALS, INC. | 2003-04-01 | — | — | US | disclosed |
| US-6420541-B1 | MEMBRANE PROTEIN FOR USE IN TREATING PSYCHOLOGICAL, NERVOUS SYSTEM, EATING AND SEXUAL DISORDERS | ARENA PHARMACEUTICALS, INC. | 2002-07-16 | — | — | US | disclosed |
| US-6140509-A | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | ARENA PHARMACEUTICALS, INC. (US) | 2000-10-31 | — | — | US | disclosed |
| US-6107324-A | CONTROLLING SEROTONIN | ARENA PHARMACEUTICALS INC. (US) | 2000-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110750-A9 | Coumarin derivatives with comt inhibiting activity | COMT, CYP1A1, CYP2D6 | GPR35 2731/4885MAOA 53/4885MAOB 58/4885 |
| US-20030153004-A1 | Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof | HTR2A, HTR3B, HTR6 | GPR35 77/4885MAOA 78/4885MAOB 150/4885 |
| US-20030186975-A1 | Coumarin derivatives with comt inhibiting activity | COMT, CYP1A1, CYP2D6 | GPR35 2731/4885MAOA 53/4885MAOB 58/4885 |
| US-20030224442-A1 | Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof | HTR2A, HTR5A, HTR1A | GPR35 43/4885MAOA 86/4885MAOB 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.