Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPRF | P10586 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491767 | 0.87 | PTPN1 (0.50) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL13066404 | 0.81 | PTPN1 (0.52) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL6483685 | 0.81 | HPGD (0.51) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL12904681 | 0.81 | CSF1R (0.52) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL8413609 | 0.80 | PTPN1 (0.48) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL2126462 | 0.79 | PTPN1 (0.49) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL2127382 | 0.79 | PTPN1 (0.49) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL30080217 | 0.79 | PTPN1 (0.49) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL28997534 | 0.77 | PTPN1 (0.50) | PTPN1PTPN2ALDH1A1MAPTPOLB | |
| SCHEMBL13066288 | 0.77 | ALDH1A1 (0.52) | PTPN1PTPN2ALDH1A1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261331-A1 | Substituted pyrrolopyridines | ASTRAZENECA AB (SE) | 2005-11-24 | — | — | US | claimed |
| US-20050261331-A1 | Substituted pyrrolopyridines | ASTRAZENECA AB (SE) | 2005-11-24 | — | — | US | disclosed |
| US-6960668-B2 | Process for the production of substituted thioxanthones | GREAT LAKES (UK) LIMITED (GB) | 2005-11-01 | — | — | US | disclosed |
| US-20040059133-A1 | Process for the production of substituted thioxanthones | GREAT LAKES (UK) LIMITED (GB) | 2004-03-25 | — | — | US | disclosed |
| EP-1380580-A1 | An improved process for the production of subsituted thioxanthones | Great Lakes (UK) Limited (GB) | 2004-01-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261331-A1 | Substituted pyrrolopyridines | ITK, WEE1, PDPK1 | PTPN1 474/4885PTPN2 433/4885ALDH1A1 1591/4885 |
| US-20040059133-A1 | Process for the production of substituted thioxanthones | TST, MPST, DHPS | PTPN1 835/4885PTPN2 1110/4885ALDH1A1 679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.