Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | KCNK2 | O95069 | 12/20 | 0.55 |
| ▸ | KCNK10 | P57789 | 9/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.46 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13485813 | 0.83 | TRPV1 (0.58) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL21995806 | 0.81 | TRPV1 (0.56) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL6497474 | 0.81 | PLK1 (0.61) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL10919991 | 0.78 | LMNA (0.53) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL1015553 | 0.76 | KCNK2 (0.57) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL10740573 | 0.76 | ALDH1A1 (0.50) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL6495770 | 0.76 | CES2 (0.61) | TRPV1EPHX2NPC1RAB9APTPN1 | |
| SCHEMBL16610094 | 0.76 | EPHX2 (0.58) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL16341732 | 0.75 | TRPV1 (0.57) | TRPV1KCNK2KCNK10EPHX2NR1H4 | |
| SCHEMBL2541283 | 0.75 | KIF11 (0.54) | TRPV1KCNK2KCNK10EPHX2NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |