Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | KCNK2 | O95069 | 9/20 | 0.55 |
| ▸ | KCNK10 | P57789 | 7/20 | 0.55 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | PTPRZ1 | P23471 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13485813 | 0.83 | TRPV1 (0.58) | TRPV1EPHX2NR1H4KCNK2KCNK10 | |
| SCHEMBL6497472 | 0.81 | TRPV1 (0.56) | TRPV1EPHX2NR1H4KCNK2KCNK10 | |
| SCHEMBL6497474 | 0.81 | PLK1 (0.61) | TRPV1EPHX2NR1H4KCNK2KCNK10 | |
| SCHEMBL16610094 | 0.80 | EPHX2 (0.58) | TRPV1EPHX2NR1H4KCNK2KCNK10 | |
| SCHEMBL2541283 | 0.79 | KIF11 (0.54) | TRPV1EPHX2NR1H4KCNK2KCNK10 | |
| SCHEMBL2107844 | 0.79 | OGG1 (0.61) | MPOCYP3A4KDM5ABLMGFER | |
| SCHEMBL10919991 | 0.78 | LMNA (0.53) | TRPV1EPHX2NR1H4KCNK2KCNK10 | |
| SCHEMBL17124383 | 0.78 | MPO (0.61) | MPOCYP3A4KDM5ABLMGFER | |
| Trifluoroacetic Acid SCHEMBL2107013 | 0.77 | OGG1 (0.50) | KCNK2KCNK10MPOCYP3A4KDM5A | |
| SCHEMBL16599531 | 0.77 | EPHX2 (0.59) | TRPV1EPHX2NR1H4KCNK2KCNK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12281108-B2 | Pyrrolidinone derivatives as formyl peptide 2 receptor agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-04-22 | — | — | US | disclosed |
| CN-113166134-B | Pyrrolidone derivatives as formyl peptide 2 receptor agonists | 百时美施贵宝公司 | 2024-06-14 | — | — | CN | disclosed |
| EP-3887366-B1 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-27 | — | — | EP | disclosed |
| US-20220002281-A1 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2022-01-06 | — | — | US | disclosed |
| EP-3887366-A1 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS | Bristol-Myers Squibb Company (US) | 2021-10-06 | — | — | EP | disclosed |
| CN-113166134-A | Pyrrolidone derivatives as formyl peptide 2 receptor agonists | 百时美施贵宝公司 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020112583-A1 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-06-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12281108-B2 | Pyrrolidinone derivatives as formyl peptide 2 receptor agonists | FPR1, FPR2, FPR3 | TRPV1 367/4885EPHX2 1881/4885NR1H4 175/4885 |
| US-20220002281-A1 | PYRROLIDINONE DERIVATIVES AS FORMYL PEPTIDE 2 RECEPTOR AGONISTS | FPR1, FPR2, FPR3 | TRPV1 367/4885EPHX2 1881/4885NR1H4 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.