SCHEMBL6498083

SCHEMBL6498083

Cc1cc(Br)cc2c1nc(C)n2Cc1ncc(Cl)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DCTPP1 Q9H773 14/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
PDE10A Q9Y233 1/20 0.33
GALR3 O60755 2/20 0.33
NR2F2 P24468 2/20 0.33
RAB9A P51151 1/20 0.31
HTR6 P50406 1/20 0.31
HSD17B13 Q7Z5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6490507 0.85 TDP1 (0.39) L3MBTL1RAB9A
SCHEMBL6490954 0.79 TSHR (0.42) DCTPP1L3MBTL1GALR3NR2F2RAB9A
SCHEMBL6491201 0.76 MCL1 (0.43)
SCHEMBL6498538 0.75 DCTPP1 (0.44) DCTPP1L3MBTL1GALR3NR2F2RAB9A
SCHEMBL6487328 0.74 RXRA (0.40) DCTPP1
SCHEMBL6502360 0.74 PABPC1 (0.39)
SCHEMBL6501927 0.72 GPR35 (0.35) DCTPP1L3MBTL1HSD17B13
SCHEMBL6501064 0.72 PIK3C2B (0.38) DCTPP1
SCHEMBL6491005 0.72 BCL2 (0.47)
SCHEMBL6490020 0.71 DCTPP1 (0.39) DCTPP1HSD17B13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD DCTPP1 1534/4885L3MBTL1 790/4885PDE10A 1140/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.